Determining the toughest course in India can be subjective and depends on various factors, such as individual strengths, interests, and aptitude. However, there are some courses known for their challenging nature and rigorous curriculum. Here are a few examples:

1. Bachelor of Medicine, Bachelor of Surgery (MBBS): Pursuing a degree in medicine involves extensive theoretical knowledge, practical training, and long hours of study. The course duration is typically five and a half years, including a one-year mandatory internship.

1. Bachelor of Architecture (B.Arch): Architecture is a demanding course that combines artistic creativity, technical skills, and theoretical knowledge. It requires a strong understanding of design principles, engineering concepts, and practical implementation.

1. Bachelor of Technology (B.Tech) in Engineering: Engineering programs in India, such as Computer Science, Electrical, Mechanical, or Civil Engineering, can be rigorous due to their intensive coursework, complex problem-solving, and practical applications.

1. Chartered Accountancy (CA): The Chartered Accountancy course involves multiple levels of exams and requires in-depth knowledge of accounting principles, taxation laws, auditing, and financial management. It demands long study hours and a high level of commitment.

1. Bachelor of Laws (LLB): Pursuing a law degree requires comprehensive legal knowledge, analytical thinking, and effective communication skills. The curriculum covers a wide range of subjects and involves extensive research, case studies, and legal drafting.

1. Bachelor of Science (B.Sc.) in Mathematics: A B.Sc. in Mathematics can be challenging due to its abstract and complex nature. The course involves advanced mathematical concepts, proofs, and rigorous problem-solving.

These are just a few examples, and there are numerous other courses that can be academically demanding in India. It’s important to remember that the difficulty of a course can vary from person to person, and what may be challenging for one individual might not be the same for another.